Vincent Duong

XL-MS and De Novo Protein Design Identified a Common Motif for TREM2 Binding

Abstract Apolipoprotein E (APOE) and triggering receptor expressed on myeloid cells 2 (TREM2) are the two strongest genetic risk factors of late-onset Alzheimer’s disease. ApoE binds to the low-density lipoprotein receptor (LDLR) to facilitate the uptake of ApoE-lipoprotein parti...