Vicente-Manzanares Miguel

Paclitaxel induces NM2 ‐dependent cellular contraction through GEF ‐ H1 dissociation from microtubules and RhoA / ROCK activation in cancer cells

In this study, we have investigated the crosstalk between microtubule dynamics and actomyosin contractility in cancer cells treated with taxanes, which are chemotherapeutic agents used to treat solid tumors. We found that paclitaxel (PTXL) induced cell contraction through a mecha...