Vesla I. Kullaya

Microbiome-wide PheWAS links gut microbial SNVs to health and exposures

Abstract The importance of the gut microbiome in human health has been widely recognized, with alterations in species abundances now reported for many different diseases. In recent years, observations of within-species genetic diversity and strain-level functional differences hav...

Distinct transcriptional remodeling of immune and metabolic pathways in severe undernutrition during latent tuberculosis infection does not consistently predict tuberculosis progression across independent cohorts

Background: Undernutrition increases tuberculosis (TB) risk, but whether severe undernutrition during latent TB infection (LTBI) produces blood transcriptional changes that resemble active disease or identify future TB remains unclear. Methods: We reanalyzed whole-blood RNA seque...