Vamsi Krishna Polavarapu

RAS pathway mutations orchestrate chromatin reconfiguration and transcriptional rewiring in colorectal cancer

Abstract Background RAS pathway mutations occur in ~ 40% of colorectal cancers (CRCs), with KRAS- and BRAF- mutant tumors exhibiting distinct mutational, transcriptional, and epigenetic landscapes. Advances in next-generation sequencing enable integrated analyses of multi-omics d...