Valérie Widmer

Perioperative myeloid cell remodeling shapes CAR-T cell efficacy in glioblastoma

Abstract Glioblastoma (GBM) is characterized by a profoundly immunosuppressive tumor microenvironment (TME) that constrains the efficacy of chimeric antigen receptor (CAR)-T cell therapy. Here, we show that surgical resection in both male mice and human GBM ex vivo induces a rapi...