Umar Farooq

Dimer-interface effects on tetramer stabilization and tryptophan dynamics in allosterically modulated TPH-II

Tryptophan hydroxylase-II (TPH-II) controls the rate-limiting step of neuronal serotonin biosynthesis and plays a central role in neuropsychiatric health. As proper tetramer formation is essential for TPH-II stability and function, targeting its quaternary structure through allos...