Uma M Neelathi

Loss of Hippo Signaling Causes Coloboma via Steric Obstruction of Optic Fissure Fusion

Purpose: Pathogenic variants in the Hippo pathway effector YAP1 causes uveal coloboma in humans, a potentially blinding congenital eye malformation resulting from failure of optic fissure (OF) closure. Here, we characterize the pathogenesis of coloboma in zebrafish lacking the Hi...