Ulrich Schotten

Atrial cardiomyopathy: from knowledge gaps to clinical impact

Abstract Background Atrial cardiomyopathy (AtCM) is increasingly recognised as an underlying atrial substrate contributing to atrial fibrillation (AF), heart failure (HF), and cardio-embolic stroke. However, diagnostic criteria, disease thresholds, and targeted treatment strategi...

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

AIMS: In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger Ca2+ transients. However, the role of lysosomal Ca2+ signals in pacemaker act...

A structural cardiac pathway mediates the risk of ischemic heart disease from TyG-related indices: A prospective cohort study

The triglyceride-glucose (TyG) index and its derivatives are surrogate markers of insulin resistance and are closely associated with cardiovascular risk. However, whether and to what extent they are associated with IHD risk through subclinical cardiac remodeling remains unclear....