Ulrich Kleinekathöfer

Leveraging Electroosmosis in OmpF for Robust Peptide Sensing

Abstract Peptide sensing and sequencing are essential for elucidating sequence-function relationships and evaluating the peptide drug quality. Nanopore electrochemistry enables label-free characterization of peptide composition, structure, and interactions at the single-molecule...

A self-assembled peptide forms α-helical nanopores for ultrasensitive biomarker profiling

α-Helical nanopores are attractive molecular sensors, yet their rational design and assembly remain challenging. Here we show that the single peptide pPorA, derived from porin PorACj, self-assembles into flexible α-helical nanopores, inserts in lipid membranes and exists in disti...