Ulf Dittmer

Interferome profiling in the blood links IFNα5-Mucin-1 axis to HIV-1 pathogenesis

ABSTRACT Type I interferons (IFN-Is) are essential for antiviral immunity, but contribute to immune dysfunction during chronic HIV-1 infection. IFN-Is comprise multiple IFNα subtypes that signal through a common receptor yet exhibit distinct biological activities, but their quali...

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

ABSTRACT Natural killer (NK) cells are innate immune cells that eliminate virus‐infected and tumour cells by a plethora of signalling pathways, involving the production of cytokines and cytotoxic molecules. NK cell activation and functions demand substantial energy and fatty acid...