Ubong S. Ekperikpe

A Vagal–Renal–Splenic Reflex Suppresses Renal Sympathetic Nerve Activity and Preserves Kidney Function After Ischemic Injury

Background: Acute kidney injury (AKI) is associated with maladaptive increases in renal sympathetic nerve activity (RSNA) and frequently progresses to chronic kidney disease. Neuromodulatory strategies that suppress sympathetic outflow may provide therapeutic benefit. We tested w...

Effects of early adulthood chronic sleep disruption on late life cognition, brain pathology, and microglial reactivity in the PS19 mouse model of tauopathy

Abstract A bidirectional relationship has been proposed between sleep and Alzheimer’s disease pathology, such that disruption to sleep can lead to increases in the expression of tau or its phosphorylation. Over the long term, this can potentially lead to greater expression of neu...