Tyler Skaddy

Telmisartan for Apolipoprotein E ε4 Carriers as a Candidate Precision Medicine Strategy in Alzheimer’s Disease

The apolipoprotein E ε4 (APOE ε4) allele is the strongest common genetic risk factor for late-onset Alzheimer’s disease and is associated with blood–brain barrier (BBB) dysfunction, cerebrovascular instability, impaired lipid transport, and metabolic dysregulation. These features...