Travis Dudding

Cascade Remodeling through Late-Stage Electrophilic Fluorination in a Bis-Spiroketal Framework

Abstract Cascade reactions efficiently generate molecular complexity but are often incompatible with the late-stage diversification of highly functionalized natural products due to competing degradation pathways. Herein, we demonstrate that electrophilic fluorination can serve as...

A Catalytic Pocket Hidden in Plain Sight: A Metal-Free Platform for Fluorinated Compounds

Abstract A defining challenge in catalyst design is the development of simple molecular platforms capable of organizing complex reactivity through cooperative interactions. Herein, we apply this concept to the synthesis of O-difluoroalkylhydroxylamine (FON) derivatives, an emergi...

Deprotonation and Alkylation of Weakly Acidic C(sp 3 )─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium tert ‐Butoxide

ABSTRACT The direct deprotonation of weakly acidic C(sp 3 )─H bonds remains a fundamental strategy for generating carbon nucleophiles, but typically requires strong bases, cryogenic conditions, and stepwise protocols. A general method enabling single‐step deprotonation and alkyla...

Deprotonation and Alkylation of Weakly Acidic C(sp 3 )─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium tert ‐Butoxide

ABSTRACT The direct deprotonation of weakly acidic C(sp 3 )─H bonds remains a fundamental strategy for generating carbon nucleophiles, but typically requires strong bases, cryogenic conditions, and stepwise protocols. A general method enabling single‐step deprotonation and alkyla...