Toshiyuki Kakumoto

Subthreshold early white-matter hyperintensity increase predicts accelerated hippocampal and whole-brain atrophy in anti-amyloid-β immunotherapy

Background Anti-amyloid-β (anti-Aβ) therapy slows cognitive decline but paradoxically accelerates whole-brain gray matter atrophy, complicating outcome prediction. Objective To identify early imaging markers that predict long-term prognoses. Methods This longitudinal cohort study...