Toshitomo Sugisaki

Glucocorticoids directly inhibit insulin biosynthesis via the glucocorticoid receptor in pancreatic β-cells

Glucocorticoids induce hyperglycemia by promoting hepatic gluconeogenesis and impairing insulin sensitivity in peripheral tissues. However, their direct effects on pancreatic β-cells remained poorly understood. This study investigated whether glucocorticoids directly impair insul...