Toshitaka Nagao

A novel machine-learning model using nuclear features to predict upper tract urothelial carcinoma recurrence

Abstract Upper-tract urothelial carcinoma (UTUC) is rare, constitutes < 5% of urothelial cancers, and, given its insidious clinical presentation, is typically diagnosed at advanced stages; post-radical nephroureterectomy recurrence remains challenging. Postoperative management is...

Mechanosensitive Stanniocalcin-1 Suppresses Pulmonary Artery Smooth Muscle Cell Proliferation and Attenuates Experimental Pulmonary Hypertension

BACKGROUND: Idiopathic pulmonary arterial hypertension (IPAH) is driven by progressive vascular remodeling, particularly smooth muscle cell (SMC) proliferation. Current combination vasodilator therapies have markedly improved outcomes; however, prognosis remains poor in subgroups...