Toshihiko Takeiwa

SYK inhibitor fostamatinib promotes mitochondrial respiratory chain supercomplex formation and improves skeletal muscle function in aged mice

Mitochondria are major organelles involved in energy metabolism and play a crucial role in the function of muscular tissues. Mitochondrial respiratory chain (MRC) complexes are assembled to higher-order “MRC supercomplex (SC)” structures, which has been suggested to promote energ...