Toshifumi Wakai

Metachronous hepatocellular carcinoma in a patient with Fontan physiology and type I congenital absence of the portal vein: repeat hepatectomy in the setting of dual abnormal hepatic hemodynamics: a case report

Fontan-associated liver disease is a recognized long-term consequence of the Fontan circulation and may progress to cirrhosis and hepatocellular carcinoma (HCC). Congenital absence of the portal vein (CAPV) is another rare vascular abnormality associated with hepatocellular nodul...

Allele-specific directionality and evolutionary timing of BRCA1/2 loss of heterozygosity in gastric cancer

Abstract Germline pathogenic variants in BRCA1 and BRCA2 are established cancer predisposition factors, but their biological role in gastric cancer remains poorly defined. We investigated whether BRCA1/2 -associated gastric cancers acquire loss of heterozygosity, which allele is...