Toni McHugh

RNA degradation by DIS3 is a necessary step in the resolution of backtracked transcription complexes

Summary The RNA exosome is known to participate in transcription, but the contribution of its ribonuclease activities to this process remains unclear. Here we investigated the role of DIS3, one of the exosome ribonucleases, in transcription by RNA polymerase II (RNAPII). Rapid de...