Todd Holyoak

The C117D oxidation mimic reveals the monomeric structure of SARS ‐ CoV ‐2 main protease

Abstract The SARS‐CoV‐2 main protease (M pro ) is essential for viral replication and functions as a homodimer, with dimerization being critical for catalytic activity. M pro contains an unusually high number of cysteine residues. Among these, C117 and the catalytic nucleophile C...