Timothy P. Cripe

Optimizing combinatorial macrophage induced innate immunotherapy against Ewing sarcoma

Abstract Background We previously reported that Ewing sarcoma (ES), a pediatric bone and soft tissue tumor, escapes macrophage phagocytosis by upregulating the CD47 “don’t eat me” signal and downregulating the cell-surface calreticulin (csCRT) “eat me” signal. Targeting this dual...