Timothy Noël

Machine Learning-Guided Discovery of Robust Conditions for Photochemical Nickel-Catalyzed Cysteine Arylation

Abstract Late-stage functionalization (LSF) of peptides offers direct access to structurally diverse analogues, but developing general, chemoselective protocols remains challenging due to the complexity of peptide substrates and the vast number of reaction variables. Traditional...

Radical Disconnection Logic Enables Direct Conversion of α-Amino Acids into Differentiated Vicinal Diamines

Abstract Functional group interconversions (FGIs) are foundational to synthesis, yet classical acid-to-aminomethyl transformations remain intrinsically step- and redox-intensive. Here we introduce a radical disconnection strategy that enables the direct conversion of α-amino acid...

Uncoupling of the allosteric signalling network in the β1-adrenergic receptor by a negative allosteric modulator

Abstract Allosteric modulation is a fundamental aspect of G protein-coupled receptor (GPCR) regulation where molecules that bind to alternative sites outside the orthosteric pocket alter agonist-induced signalling responses. The advantages of allosteric modulators over traditiona...