Timothy J. Jarome

Estradiol-dependent memory and hippocampal spine remodeling require proteasomal protein degradation

Although 17β-estradiol (E 2 ) is a critical neuromodulator of hippocampus-dependent memory and synaptic plasticity, the molecular mechanisms underlying these effects remain incompletely understood. Previous studies showed that E 2 enhances dorsal hippocampus-dependent memory cons...