Tim G. Hales

Enhancement of hippocampal synaptic AMPA receptor function by the antidepressant tianeptine and by opioid peptides

Management of major depressive disorder (MDD) with conventional therapeutics that enhance monoaminergic neurotransmission requires prolonged treatment prior to clinical benefit and a substantial proportion of patients show little or no improvement. Identifying alternative molecul...

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

Background and Purpose Opioids, such as morphine, are effective analgesics, but their persistent use is compromised by tolerance. In mice, tolerance is attenuated by β‐arrestin2 depletion or Src‐family kinase inhibitors, which may act through off‐target effects. We tested the eff...