Tim G. Hales

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

Background and Purpose Opioids, such as morphine, are effective analgesics, but their persistent use is compromised by tolerance. In mice, tolerance is attenuated by β‐arrestin2 depletion or Src‐family kinase inhibitors, which may act through off‐target effects. We tested the eff...