Tianjiao Zhu

Discovery of an Iterative Terminal Condensation Domain Catalyzing Sequential Ester and Amide Bond Formation in Fungal Polyketide Synthase–Nonribosomal Peptide Synthetase Biosynthesis

Abstract Fungal polyketide–nonribosomal peptide (PK–NRP) hybrids are typically assembled by condensation (C) domains that form an amide bond between a polyketide and an amino acid unit. Here, we describe a family of bis-anthranilated PK–NRP hybrids, Neodiabzacids A and B, in whic...