Tianchen Ren

SUMO2 deletion changes chromatin accessibility and enhances cytotoxic T cell activation and tumor infiltration

Cytotoxic T cells [cytotoxic lymphocytes (CTLs)] are crucial for adaptive immunity leading to prolonged survival and potential cures for cancer. Recent clinical data have shown that pharmacological inhibition modifies the tumor microenvironment (TME) and activates CTLs, although...