Thomas Michael Best

Mechanical Loading Reshapes Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicle microRNA Cargo Toward Predicted Immunomodulatory and EV Cargo-Trafficking Pathways: An In Vitro Mechanobiology Study

Mesenchymal stem/stromal cell-derived extracellular vesicles (MSC-EVs) are emerging as cell-free therapeutic candidates for osteoarthritis, but most approaches treat the secretome as a passively collected product rather than a tunable biologic. Because joint loading regulates car...