Thomas Magauer

Synthetic Strategies for Oxygenated Cyclohexanoid Frameworks

Highly oxygenated cyclohexanoid frameworks are key structural features in many natural products and remain challenging synthetic targets. Herein, we report investigations into two strategies for their preparation. A high-pressure Diels-Alder reaction enabled the construction of a...

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Lipidomics-guided screening of unexplored natural product chemical space provides access to small molecules that globally reprogram cellular lipid profiles. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp. reshapes immune cell lipidomes, shifting them from...