Thomas L. Kukar

Monospecific antibodies reveal reduction of granulins in frontotemporal dementia caused by GRN mutations

Loss-of-function mutations in the progranulin (PGRN) gene ( GRN ) are a major cause of Frontotemporal dementia (FTD), also known as frontotemporal lobar degeneration (FTLD). PGRN is a lysosomal protein implicated in neuroprotection, proteostasis, and regulation of lipids includin...