Thomas Happe

A Histidine-Mediated, Pendulum-Like Proton Transport Mechanism Is Required for the High Catalytic Activity of [FeFe]-Hydrogenases

Abstract [FeFe]-hydrogenases are molecular hydrogen (H2) converting enzymes that employ a hexanuclear iron complex, the H-cluster, as the catalytic cofactor, and a proton transfer pathway (PTP) that enables efficient proton-coupled electron transfer (PCET). Recent phylogenetic an...