Thomas G. Graeber

Coenzyme A activates TLR4 and enhances alternative macrophage activation in line with MyD88 agonism

Abstract Metabolites and metabolic cofactors can shape the innate immune response, though the pathways by which these molecules adjust inflammation remain incompletely understood. Here we show that the metabolic cofactor coenzyme A (CoA) enhances IL-4 driven alternative macrophag...