Thomas Filsecker

Neurogenic Rosacea as a Lyapunov‑Stabilisable System: A Control‑Theoretic Framework for Rogue Neuroimmune Loops

Rosacea affects roughly $5\%$ of adults worldwide [1, 2], yet patients with prominent neurogenic features often remain refractory to standard anti‑inflammatory or vasomotor therapies [5, 6]. We propose that this recalcitrant subset is best understood through a control‑theoretic l...

Seed-Triggered Onset of Neoclassical Tearing Modes: A Minimal Bifurcation Model and an Open Empirical Test

Neoclassical tearing modes (NTMs) are a principal performance limit in tokamak plasmas: magnetic islands sustained by a helically perturbed bootstrap current, linearly stable yet nonlinearly unstable, and generally requiring a finite "seed" perturbation to trigger sustained growt...

Destabilised Neuroimmune Feedback Loops: A Control-Theoretic Framework and Its Application to Rosacea

The past two decades have witnessed a steady shift in our understanding of chronic inflammatorydisease - from linear cascades to regulated circuits, complete with feedback, amplification, and sus-ceptibility to runaway behaviour. Systems biologists have long emphasised that biolo...

Seed-Triggered Onset of Neoclassical Tearing Modes: A Minimal Bifurcation Model and an Open Empirical Test

Neoclassical tearing modes (NTMs) are a principal performance limit in tokamak plasmas: magnetic islands sustained by a helically perturbed bootstrap current, linearly stable yet nonlinearly unstable, and generally requiring a finite "seed" perturbation to trigger sustained growt...

Seed-Triggered Onset of Neoclassical Tearing Modes: A Minimal Bifurcation Model and an Open Empirical Test

Neoclassical tearing modes (NTMs) are a principal performance limit in tokamak plasmas: magnetic islands sustained by a helically perturbed bootstrap current, linearly stable yet nonlinearly unstable, and generally requiring a finite "seed" perturbation to trigger sustained growt...

The GABA-B – Substance P–Histamine Axis: A Unifying Mechanism for Neurogenic Inflammation

Neurogenic inflammation—the process by which sensory neurones release neuropeptides that activate immune cells—is increasingly recognised as a pathogenic mechanism in a range of chronic inflammatory conditions, including rosacea, chronic pruritus, and mast cell-mediated dermatose...