Thomas E. Prisinzano

Bridging tumor growth dynamics and survival in preclinical oncology drug development – a Tumor Growth Inhibition and Time-to-Event (TGI-TTE) modeling framework

To develop a tumor growth inhibition and time-to-event (TGI-TTE) modeling framework linking drug exposure, tumor dynamics, and survival. Modeling used preclinical efficacy studies with MTMSA-Trp, a preclinical-stage anti-tumor agent for Ewing sarcoma. Tumor volume and survival da...