Thomas D. Beckler

Synthesis of 1,3-Dihydro-2,1-benzisoxazoles by Intramolecular C–N Coupling: Evaluation as an Indane Bioisostere

Abstract Despite the ever-increasing interest in isoxazole-based compounds, benzo-fused isoxazolidines, or 1,3-dihydro-2,1-benzisoxazoles, are very rare. Seeking to fill this gap, we present a method for the synthesis of 1,3-dihydro-2,1-benzisoxazoles by intramolecular Cu-mediate...