Thomas Charles Heineman

MicroRNA-driven regulation of immunosuppressive microenvironment in hepatocellular carcinoma

We investigated the role of tumor microenvironment (TME) in evolution of liver cirrhosis to hepatocellular carcinoma (HCC). Nonmalignant hepatic tissues, including chronic hepatitis and cirrhosis, retained expression of liver specific miR-122 and hepatocyte nuclear factor 4 (HNF-...