Thomas C. Friedrich

Exposure route, not dose, is the primary driver of infection patterns for a respiratory virus

Infectious disease severity, shedding, and within-host kinetics can vary substantially with exposure dose, inoculation route, and host factors. However, the relative contributions of these variables to infection heterogeneity remain poorly quantified because small sample sizes in...

Evaluation of a Zika virus-like particle-based vaccine in a highly penetrant non-human primate model of congenital infection

Zika virus (ZIKV) is an arthropod-borne Orthoflavivirus that caused a major outbreak in Central and South America in 2015–16. During that outbreak, ZIKV infection during pregnancy was associated with high rates of adverse outcomes, including miscarriage and a spectrum of neurolog...