Theresa Alenghat

Early-life microbiota direct an epithelial S100 program required for neonatal immunity

Despite appreciation that neonatal immune responses differ markedly from those of adults, the mechanisms that enable early-life immunity remain poorly understood. Here, we find that healthy newborn mice express high concentrations of the S100 calcium-binding protein A8/A9 (S100A8...

Machine Learning Guided Discovery of Microbiome Metabolites That Inhibit HDAC

Abstract Histone deacetylase (HDAC) is a family of key epigenetic regulator implicated in inflammation, metabolism, and cancer. Microbiome metabolites can modulate host histone acetylation, yet systematic identification of metabolites that target HDAC remains limited. Here we pre...