Tetsuya Tsukamoto

ADA2high tumor cell-derived inosine induces an immunosuppressive microenvironment in gastric cancer by promoting macrophage M2 polarization

Abstract Metabolic alterations within the tumor microenvironment (TME) can reshape the polarization state of tumor-associated macrophages (TAMs) and weaken antitumor immunity, yet the underlying mechanisms remain unclear. In this study, we integrated multiple gastric cancer (GC)...