Teo Yang

Validated but unconstrained: why total-clearance data cannot constrain minor elimination pathways, and how a thirtyfold parameter revision went undetected in ocular pharmacokinetics

Mechanistic models in drug development are validated against quantities that can be measured and then used to predict quantities that cannot. This work shows that the inference from one to the other is quantifiable, and often close to empty. When the validation target is a total...