Taylor R. Ausec

Engineered Deoxyribonucleic Acid-Tunable Spheroid Platform for Analysis of Tumor-Macrophage Interactions

Abstract Tumor architecture strongly influences immune cell behavior, yet the individual contributions of cell-cell spacing and hypoxia remain difficult to isolate in vivo. Here, we use a DNA-programmable 3D tumor spheroid platform to generate 4T1 spheroids with tunable intercell...