Tao Wang

Discovery of Neutral and Cerebrospinal Fluid Penetrant Transthyretin (TTR) Stabilizers with Heterocyclic Linkers

Abstract Human transthyretin (TTR) is associated with ATTR amyloidosis. Despite having approved agents against TTR, there is still an unmet medical need to develop novel agents, especially those that could have therapeutic effects in cerebrospinal fluid (CSF). Structure-based dru...

Benchmarking of pathology foundation models for assessing HER2 amplification and CEP17 polysomy in breast cancer

Abstract Accurate assessment of Human Epidermal Growth Factor Receptor 2 (HER2) amplification and Chromosome 17 (CEP17) copy number is critical for breast cancer treatment, yet diagnostically equivocal (IHC 2+) cases remain a clinical bottleneck. This study systematically benchma...