Tamotsu Kiyoshima

ARL4C in oral cancer cells promotes stromal RANKL expression via a RelA-dependent inflammatory axis in stromal fibroblasts

Abstract Purpose Jawbone destruction in oral squamous cell carcinoma (OSCC) is driven by receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-mediated osteoclastogenesis. Although the cellular sources of RANKL and its regulatory mechanisms within the OSCC microenvironme...