Tam D. Ho

Synthesis of α-Halophosphonates via Copper-Catalyzed Atom Transfer Radical Addition

Abstract α-Substituted alkylphosphonates and phosphates have broad utility in the pharmaceutical, agrochemical, and commodity chemical industries. Herein, we present the copper-catalyzed atom transfer radical addition (ATRA) of alkyl halides to alkenylphosphonates for the synthes...