Takuma Sato

Copper-Catalyzed 1,3-Propargyl Shift: Development of an Anionic Rearrangement of ortho -Metalated Aryl Propargyl Ethers

Abstract A novel anionic [1,3]-rearrangement of ortho-metalated aryl propargyl ethers was developed. A catalytic amount of copper(I) salt efficiently promotes the 1,3-shift of a propargyl group from an oxygen atom to a carbon atom in an aryl magnesium species, affording phenol de...

Enantioselective and Divergent Synthesis of Propargylamides and Allenamides from Alkynyl Diazoketones and Anilines via Organocatalytic Wolff Rearrangements

Abstract Chiral allenes and alkynes are privileged scaffolds in natural products and pharmaceuticals. Although significant advances have been achieved in catalytic asymmetric synthesis from diazo compounds, selectively achieving high levels of both enantioselectivity and regiosel...