Takeshi Marumo

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1 ‐Dependent Suppression of ROMK

ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous...