Takayuki Doi

Total Synthesis of the Antifungal Clinical Candidate ASP2397 Cyclohexapeptide Facilitated by the Chemo-selective Reduction of Secondary N -Benzyloxyamides

Abstract ASP2397 is a siderophore-like cyclic hexapeptide with potent and rapid fungicidal activity against Aspergillus species. We report here its first total synthesis, enabled by an unprecedented one-pot chemoselective reduction of secondary N-benzyloxyamides that strictly pre...