Takanori Takebe

Matrix Stiffness Modulates 3D Spheroid-Derived Extracellular Vesicle Profiles and Discovery of Piezo1 Cargo

Abstract Background Increased extracellular matrix stiffness is a defining mechanical feature of solid tumors, yet how it regulates extracellular vesicle-mediated intercellular communication remains poorly understood in three-dimensional tumor microenvironments. Here, we demonstr...