Takaki Tsunoda

Longitudinal comparison of serum creatinine, estimated glomerular filtration rate, and blood urea nitrogen-to-creatinine ratio after initiation of palbociclib or abemaciclib: A single-center retrospective study

Introduction Abemaciclib inhibits renal tubular creatinine secretion and can increase serum creatinine without a true reduction in glomerular filtration rate. Direct real-world comparisons with palbociclib using routinely available laboratory markers are limited. Methods We condu...

Longitudinal Changes in the Blood Urea Nitrogen-to-Creatinine Ratio After Initiation of Abemaciclib: A Single-Center Retrospective Observational Study

Serum creatinine (Cr) elevation is frequently observed after the initiation of abemaciclib treatment. Because abemaciclib inhibits tubular creatinine secretion, Cr may increase without a true decline in glomerular filtration rate. In Japan, cystatin C is not routinely measured in...