Takahiko Kawashima

Aberrant salience is selectively associated with ventral midbrain connectivity to the dorsal but not ventral striatum

The dorsal midbrain-striatal dopaminergic stream encodes salience in animals, while it’s unknown in humans. The midbrain-striatal dopaminergic hyperactivity is postulated to attribute aberrantly-heightened salience to ordinary stimuli, forming delusion and hallucination. While an...