Tai‐Yen Chen

CTR1 as a transporter–organizer in copper signaling: molecular state, trafficking, and protein interactions

Copper transporter 1 (CTR1, encoded by SLC31A1 ) is best known as a high-affinity copper importer, yet several CTR1-dependent signaling outputs are not readily explained by bulk intracellular copper abundance alone. CTR1 has also been linked to growth-factor signaling, kinase reg...

Quantitative In-Cell Localization Microscopy: From Single-Molecule Localizations to Mechanistic Inference

Abstract Quantitative in-cell localization microscopy can reveal nanoscale molecular organization, but the biological strength of a localization-derived claim depends on more than localization precision. Blinking, incomplete labeling, molecular motion, background heterogeneity, a...